alpha-mannosidase 2x; alpha-mannosidase IIx; man IIx; mannosidase alpha class 2A member 2; mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase (MAN2A2, MANA2X)

Function

• protein modification; protein glycosylation
• catalyzes the 1st committed step in the biosynthesis of complex N-glycans (N-glycosylation)
• controls conversion of high mannose to complex N-glycans
• final hydrolytic step in the N-glycan maturation

Cofactor: binds 1 Zn+2 per subunit (putative)

Structure

• homodimer, disulfide-linked
• belongs to the glycosyl hydrolase 38 family

Compartment

• Golgi membrane
• single-pass type 2 membrane protein (putative)

Alternative splicing

• named isoforms=2
• at least one isoform may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay

More general terms

• glycosidase (glycoside hydrolase)
• membrane protein
• glycoprotein

Additional terms

• Asn glycosylation

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4122
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4122
• OMIM: https://mirror.omim.org/entry/600988
• UniProt: http://www.uniprot.org/uniprot/P49641.html