galactosylceramide sulfotransferase; galcer sulfotransferase; 3'-phosphoadenosine-5'-phosphosulfate:galcer sulfotransferase; 3'-phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase; cerebroside sulfotransferase (GAL3ST1, CST)

Function

• catalyzes sulfation of membrane glycolipids
• seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety
• catalyzes synthesis of galactosylceramide sulfate (sulfatide), a major lipid component of the myelin sheath & of monogalactosylalkylacylglycerol sulfate (seminolipid), present in spermatocytes (putative)
• also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol & galactosyl diacylglycerol (in vitro)
• lipid metabolism; sphingolipid metabolism

3'-phosphoadenylyl sulfate + galactosylceramide = adenosine 3',5'-bisphosphate + galactosylceramidesulfate

3'-phosphoadenylyl sulfate + monogalactosylalkylacylglycerol = adenosine 3',5'-bisphosphate + monogalactosylalkylacylglycerol sulfate

Structure

• belongs to the galactose-3-O-sulfotransferase family

Compartment

• Golgi membrane; single-pass type 2 membrane protein (putative)

Expression

• expressed in kidney proximal tubule, gastric mucosa

Pathology

• expressed in adenocarcinomas
• highly expressed in renal cell carcinoma cell lines

More general terms

• sulfotransferase
• glycoprotein
• membrane protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9514
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9514
• OMIM: https://mirror.omim.org/entry/602300
• UniProt: http://www.uniprot.org/uniprot/Q99999.html