heparan sulfate glucosamine 3-O-sulfotransferase 6; heparan sulfate D-glucosaminyl 3-O-sulfotransferase 6; 3-OST-6; heparan sulfate 3-O-sulfotransferase 6; h3-OST-6 (HS3ST6)

Function

• transfers a sulfuryl group to heparan sulfate
• unlike HS3ST1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate

3'-phosphoadenylyl sulfate + [[[A18449|heparan sulfate]]]-glucosamine = adenosine 3',5'-bisphosphate + [[[A18449|heparan sulfate]]]-glucosamine 3-sulfate

Structure

belongs to the sulfotransferase 1 family

Compartment

• Golgi membrane; single-pass type 2 membrane protein (probable)

Pathology

• substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor for Herpes simplex virus-1 (HSV-1) & permits its entry.

More general terms

• sulfotransferase
• glycoprotein
• membrane protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q96QI5.html