heparan sulfate glucosamine 3-O-sulfotransferase 1; heparan sulfate D-glucosaminyl 3-O-sulfotransferase 1; 3-OST-1; heparan sulfate 3-O-sulfotransferase 1; h3-OST-1 (HS3ST1, 3OST, 3OST1)
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Function
- rate limiting enzyme for synthesis of Hsact
- role in biosynthesis of heparan sulfate
- confers anticoagulant property to heparin sulfate by completing the structure of the antithrombin pentasaccharide binding site
3'-phosphoadenylyl sulfate + [[[A18449|heparan sulfate]]]-glucosamine = adenosine 3',5'-bisphosphate + [[[A18449|heparan sulfate]]]-glucosamine 3-sulfate
Structure
belongs to the sulfotransferase 1 family
Compartment
Golgi apparatus lumen (probable)
Expression
- highly expressed in the brain & kidney
- weakly expressed in the heart, lung & placenta
More general terms
Additional terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/O14792.html
- ↑ GGDB; Note: glycogene database http://riodb.ibase.aist.go.jp/rcmg/ggdb/