heparan sulfate glucosamine 3-O-sulfotransferase 1; heparan sulfate D-glucosaminyl 3-O-sulfotransferase 1; 3-OST-1; heparan sulfate 3-O-sulfotransferase 1; h3-OST-1 (HS3ST1, 3OST, 3OST1)

Function

• rate limiting enzyme for synthesis of Hsact
• role in biosynthesis of heparan sulfate
  • confers anticoagulant property to heparin sulfate by completing the structure of the antithrombin pentasaccharide binding site

3'-phosphoadenylyl sulfate + [[[A18449|heparan sulfate]]]-glucosamine = adenosine 3',5'-bisphosphate + [[[A18449|heparan sulfate]]]-glucosamine 3-sulfate

Structure

belongs to the sulfotransferase 1 family

Compartment

Golgi apparatus lumen (probable)

Expression

• highly expressed in the brain & kidney
• weakly expressed in the heart, lung & placenta

More general terms

• heparan sulfate glucosamine 3-O-sulfotransferase (HS3ST)

Additional terms

• glucosamine (Cosamin, Osteo-Bi-Flex)
• heparan sulfate

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9957
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9957
• OMIM: https://mirror.omim.org/entry/603244
• UniProt: http://www.uniprot.org/uniprot/O14792.html