heparan sulfate glucosamine 3-O-sulfotransferase 5; heparan sulfate D-glucosaminyl 3-O-sulfotransferase 5; 3-OST-5; heparan sulfate 3-O-sulfotransferase 5; h3-OST-5 (HS3ST5, 3OST5, HS3OST5)

Function

• rate limiting enzyme for synthesis of Hsact
• like HS3ST1, modifies heparan sulfate to complete the structure of the antithrombin pentasaccharide binding site, thus conferring anticoagulant activity
• also generates GlcUA-GlcNS or IdoUA-GlcNS & IdoUA2S-GlcNH2

3'-phosphoadenylyl sulfate + [[[A18449|heparan sulfate]]]-glucosamine = adenosine 3',5'-bisphosphate + [[[A18449|heparan sulfate]]]-glucosamine 3-sulfate

Structure

belongs to the sulfotransferase 1 family

Compartment

• Golgi apparatus membrane
• single-pass type 2 membrane protein (probable)

Expression

• highly expressed in skeletal muscle & fetal brain
• also found in adult brain, spinal cord, cerebellum & colon

Pathology

• substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) & permits its entry

More general terms

• sulfotransferase
• glycoprotein
• membrane protein

Additional terms

• glucosamine (Cosamin, Osteo-Bi-Flex)
• heparan sulfate

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=222537
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:222537
• OMIM: https://mirror.omim.org/entry/609407
• UniProt: http://www.uniprot.org/uniprot/Q8IZT8.html