K+ voltage-gated channel subfamily C member 2 (voltage-gated K+ channel Kv3.2, KCNC2)

Function

• mediates the voltage-dependent K+ permeability of excitable membranes
• forms a K+-selective channel through which K+ may pass in accordance with their electrochemical gradient
• channel properties are modulated by subunit assembly (putative)
• the K+ channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits that can associate with modulating accessory subunits
• interacts with KCNC1, KCNE1, KCNE2 & KCNE3 (putative)

Structure

• segment S4 is probably the voltage-sensor & is characterized by a series of positively charged amino acids at every third position
• tail may be important in modulation of channel activity &/or targeting of the channel to specific subcellular compartments
• belongs to the K+ channel family, C (Shaw) subfamily

Compartment

membrane

Alternative splicing

named isoforms=4

More general terms

• transmembrane 6 protein
• K+ channel subfamily C
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/176256
• UniProt: http://www.uniprot.org/uniprot/Q96PR1.html