K+ voltage-gated channel subfamily C member 1; NGK2; voltage-gated K+ channel subunit Kv3.1; voltage-gated K+ channel subunit Kv4 (KCNC1)

Function

• mediates voltage-dependent K+ permeability of excitable membranes
• channels open or close in response to the voltage difference across the membrane
• the protein forms a K+-selective channel through which K+ may pass in accordance with the electrochemical gradient
• heteromultimer with KCNG3, KCNG4 & KCNV2

Structure

• the segment S4 is probably the voltage-sensor & is characterized by a series of positively charged amino acids at every third position
• the tail may be important in modulation of channel activity &/or targeting of the channel to specific subcellular compartments
• belongs to the K+ channel family, C (Shaw) (TC 1.A.1.2) subfamily, Kv3.1/KCNC1 sub-subfamily

Compartment

membrane

More general terms

• transmembrane 6 protein
• K+ channel subfamily C
• glycoprotein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3746
• OMIM: https://mirror.omim.org/entry/176258
• UniProt: http://www.uniprot.org/uniprot/P48547.html