K+ voltage-gated channel subfamily V member 2; voltage-gated K+ channel subunit Kv8.2 (KCNV2)

Function

• K+ channel subunit
• modulates channel activity by shifting the threshold & the half-maximal activation to more negative values
• heteromultimer with KCNB1, KCNC1 & KCNF1
• does not form homomultimers

Structure

• the segment S4 is probably the voltage-sensor & is characterized by a series of positively charged amino acids at every third position
• belongs to the K+ channel family, V (TC 1.A.1.2) subfamily, Kv8.2/KCNV2 sub-subfamily

Compartment

• cell membrane; multi-pass membrane protein
• must be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane
• remains intracellular in the absence of KCNB1

Expression

• detected in lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary & colon

Pathology

• defects in KCNV2 are the cause of retinal cone dystrophy type 3B

More general terms

• transmembrane 6 protein
• K+ channel subfamily V

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=169522
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:169522
• OMIM: https://mirror.omim.org/entry/607604
• OMIM: https://mirror.omim.org/entry/610356
• UniProt: http://www.uniprot.org/uniprot/Q8TDN2.html