K+ voltage-gated channel subfamily G member 4; voltage-gated K+ channel subunit Kv6.4 (KCNG4, KCNG3)

Function

• K+ channel subunit
• modulates channel activity by shifting the threshold & the half-maximal activation to more negative values
• heteromultimer with KCNB1, KCNC1 & KCNF1
• does not form homomultimers

Structure

• the segment S4 is probably the voltage-sensor & is characterized by a series of positively charged amino acids at every third position
• belongs to the K+ channel family, G (TC 1.A.1.2) subfamily, Kv6.4/KCNG4 sub-subfamily

Compartment

• cell membrane; multi-pass membrane protein
• has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane
• remains intracellular in the absence of KCNB1

Alternative splicing

named isoforms=2

Expression

• highly expressed in brain
• expressed at lower levels in liver, small intestine & colon

More general terms

• K+ channel subfamily G
• transmembrane 6 protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=93107
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:93107
• OMIM: https://mirror.omim.org/entry/607603
• UniProt: http://www.uniprot.org/uniprot/Q8TDN1.html