cAMP responsive element-binding protein 3-like protein 2 (BBF2 human homolog on chromosome 7, CREB3L2, BBF2H7)

Function

• transcriptional activator
• may act during endoplasmic reticulum stress late phase by activating unfolded protein response target genes
• may play a role in preventing accumulation of unfolded proteins in damaged neurons
• in vitro, binds to the cAMP response element (CRE) & activates transcription through CRE
• binds DNA as a dimer
• controlled by regulated intramembrane proteolysis
• following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis

Structure

• belongs to the bZIP family, ATF subfamily.
• contains 1 bZIP domain

Compartment

• endoplasmic reticulum membrane
• processed form: nucleus
• under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus

Alternative splicing

named isoforms=3

Expression

• widely expressed
• highest levels in placenta, lung, spleen & intestine
• lowest levels in heart, brain, skeletal muscle, thymus, colon & leukocytes tissues, weakest expression is detected in brain & heart

Pathology

• chromosomal translocation t(7;16)(q33;p11) involving CREB3L2 with FUS is found in low grade fibromyxoid sarcoma

More general terms

• DNA-binding protein
• phosphoprotein
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/608834
• UniProt: http://www.uniprot.org/uniprot/Q70SY1.html