hepatitis A virus cellular receptor 1 (HAVcr-1, T cell immunoglobulin & mucin domain-containing protein 1, TIMD-1, T cell membrane protein 1, TIM-1, TIM, HAVCR1, TIM1, TIMD1)
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Function
- role in T-helper cell development (putative)
- receptor for TIMD4
Structure
- belongs to the immunoglobulin superfamily, TIM family
- contains 1 Ig-like V-type domain (immunoglobulin-like)
Compartment
membrane
Expression
- widely expressed, highest levels in kidney & testis
- expressed by activated CD4+ T-cells during development of helper T-cells responses
Pathology
- cell-surface receptor for hepatitis A virus (HAV)
- regulation of asthma & allergic diseases
Polymorphism
- HAV seropositivity protects against atopy in individuals with variants Met-Thr-Thr-Val-Pro-157 ins & Met-Thr-Thr-Thr-Val-Pro-157 ins
- reduction in HAV seroprevalence diminishes selection for atopy-protective alleles, & perhaps an increase in prevelance of atopy, i.e. asthma, allergic rhinitis & atopic dermatitis.
- allelic variation does not affect HAV-infection rates