periostin (PN, osteoblast-specific factor 2, OSF-2, POSTN, OSF2)

Function

• binds to heparin
• induces cell attachment & spreading
• role in cell adhesion

Structure

• contains 1 EMI domain.
• contains 4 FAS1 domains

Compartment

secreted, extracellular matrix

Alternative splicing

named isoforms=3

Expression

• widely expressed
• highest levels in aorta, stomach, lower gastrointestinal tract, placenta, uterus, breast

Pathology

• up-regulated in epithelial ovarian tumors
  • not expressed normal ovaries
• highly expressed at the tumor periphery of lung carcinoma tissue but not within the tumor
• overexpressed in breast cancers
  • malignant breast cancer stem cells induce fibroblasts in organs of metastases to produce periostin

More general terms

• secreted protein
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/608777
• UniProt: http://www.uniprot.org/uniprot/Q15063.html