lens fiber membrane intrinsic protein (MP18, MP19, MP20, LIM2)

Function

• found in thicker 16-17 nm junctions of mammalian lens fiber cells, may contribute to cell junctional organization
• receptor for calmodulin
• role in both lens development & cataractogenesis (putative)
• associated with itself or another lens membrane component via disulfide bonds
• phosphorylated by cAMP-dependent kinase & protein kinase C

Compartment

membrane

Alternative splicing

named isoforms=2

Expression

eye lens specific

More general terms

• transmembrane 4 protein
• phosphoprotein
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/154045
• UniProt: http://www.uniprot.org/uniprot/P55344.html