solute carrier family 13 member 4; Na+/sulfate cotransporter SUT-1; NaS2 (SLC13A4, SUT1)

Function

• Na+/sulfate cotransporter that mediates sulfate reabsorption in the high endothelial venules (HEV)

Structure

• belongs to the SLC13A transporter (TC 2.A.47) family NADC subfamily

Compartment

membrane

Expression

• highly expressed in placenta & testis
• lesser expression in brain & lower levels in heart, thymus & liver

Notes

• transport is inhibited by thiosulfate, phosphate, molybdate, selenate & tungstate
• not inhibited by oxalate, citrate, succinate, phenol red or 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS)

More general terms

• transmembrane 12e protein
• glycoprotein
• solute carrier family 13 (SLC13, SLC13A)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=26266
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:26266
• OMIM: https://mirror.omim.org/entry/604309
• UniProt: http://www.uniprot.org/uniprot/Q9UKG4.html