solute carrier family 2 member 8 (facilitated glucose transporter); glucose transporter type 8; GLUT-8; glucose transporter type X1 (SLC2A8, GLUT8, GLUTX1)

Function

• insulin-regulated facilitative glucose transporter
• binds cytochalasin B (glucose-inhibitable)
• seems to be a dual-specific sugar transporter
  • inhibitable by fructose
• interacts with AP2B1 (putative)

Structure

• belongs to the major facilitator superfamily, sugar transporter (TC 2.A.1.1) family, glucose transporter subfamily

Compartment

• cell membrane
• cytoplasmic vesicle membrane
• principally intracellular
• may move between intracellular vesicles & plasma membrane
• dileucine internalization motif is critical for intracellular sequestration (putative)

Expression

• highly expressed in testis
• lower amounts present in most other tissues
• in testis, down-regulated by estrogen

Pathology

• down-regulated in testicular carcinoma

More general terms

• glucose transporter
• glycoprotein
• solute carrier family 2 (SLC2, SLC2A)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=29988
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:29988
• OMIM: https://mirror.omim.org/entry/605245
• UniProt: http://www.uniprot.org/uniprot/Q9NY64.html