G-protein coupled receptor 17; uracil nucleotide/cysteinyl leukotriene receptor; UDP/CysLT receptor; P2Y-like receptor; R12 (GPR17)

Function

• dual specificity receptor for uracil nucleotides & cysteinyl leukotrienes (CysLTs)
• signals through Gi & inhibition of adenylyl cyclase

Structure

• belongs to the G-protein coupled receptor 1 family

Compartment

• cell membrane; multi-pass membrane protein

Alternative splicing

named isoforms=2

Expression

• expressed in brain, kidney, heart & umbilical vein endothelial cells
• highest expression in brain

Pathology

• may mediate brain damage by nucleotides & CysLTs following ischemia

More general terms

• G-protein coupled receptor; serpentine receptor
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2840
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2840
• OMIM: https://mirror.omim.org/entry/603071
• UniProt: http://www.uniprot.org/uniprot/Q13304.html