cysteinyl leukotriene receptor 2 (CysLTR2, PSEC0146, HG57, HPN321, hGPCR21)

Function

• receptor for cysteinyl leukotrienes
• G-protein-linked IP3-Ca+2 second messenger system.
• agonist induce:
  • contractions of pulmonary veins
  • relaxation of the pulmonary vascular endothelium
• affinities: LTC4 = LTD4 >> LTE4

Structure

belongs to the G-protein coupled receptor 1 family

Expression

• widely expressed
• highest levels in the heart, placenta, spleen, peripheral blood leukocytes & adrenal gland
• in lung, expressed in the interstitial macrophages, & slightly in smooth muscle cells

More general terms

• G-protein coupled receptor; serpentine receptor
• leukotriene receptor
• glycoprotein

Additional terms

• leukotriene C

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5710
• OMIM: https://mirror.omim.org/entry/605666
• UniProt: http://www.uniprot.org/uniprot/Q9NS75.html