G protein-coupled receptor 127; EGF-like module containing mucin-like hormone receptor-like 4 (GPR127, EMR4, EMR4P)

Function

• may play role in cellular interaction between myeloid cells & B-cells (putative)
• forms a heterodimer, consisting of a large extracellular region (alpha subunit) non-covalently linked to a seven- transmembrane moiety (beta subunit) (putative)
• proteolytically cleaved into 2 subunits, an extracellular alpha subunit non-covalently linked to a 7- transmembrane beta subunit

Structure

• belongs to the G-protein coupled receptor 2 family LN-TM7 subfamily
• contains 2 EGF-like domains
• contains 1 GPS domain

Compartment

cell membrane; multi-pass membrane protein

Alternative splicing

named isoforms=2

Pathology

• mutation in exon 8 would result in a truncated soluble form

Notes

• could be the product of a pseudogene
• seems to have became non-functional after human-chimpanzee speciation, about 5 million years ago

More general terms

• G-protein coupled receptor; serpentine receptor
• glycoprotein
• evolutionary divergent human protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q86SQ3.html