melanocortin receptor 4; MC4-R (MC4R)

Function

• receptor specific to the heptapeptide core common to ACTH & alpha-MSH, beta-MSH, & gamma-MSH
• signal is mediated by G proteins that stimulate adenylate cyclase
• interacts with ATRNL1 (putative)
• involved in hypothalamic signal transduction regulating appetite & response to leptin

Structure

belongs to the G-protein coupled receptor 1 family

Compartment

cell membrane

Expression

brain, placental, & gut tissues

Pathology

• MC4R gene mutation is the most common cause of autosomal dominant obesity

More general terms

• melanocortin receptor
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4160
• OMIM: https://mirror.omim.org/entry/155541
• OMIM: https://mirror.omim.org/entry/601665
• UniProt: http://www.uniprot.org/uniprot/P32245.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4160