endothelial lipase; endothelial cell-derived lipase; EDL; EL (LIPG)

Function

• phospholipase & triglyceride lipase activities
• hydrolyzes high density lipoproteins (HDL)
• binds heparin
• inhibited by serum

Structure

• head to tail homodimer
• belongs to the AB hydrolase superfamily, lipase family
• contains 1 PLAT domain

Compartment

secreted

Alternative splicing

named isoforms=2

Expression

• synthesized in endothelial cells
  • also expressed in other cell types
• expressed in liver, placenta, lung, thyroid, kidney, testis, corpus luteum of ovary, coronary artery endothelial cells, umbilical vein endothelial cells, hepatocyte & osteosarcoma cell lines
• not detected in heart, brain, muscle

More general terms

• lipase
• secreted protein
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9388
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9388
• OMIM: https://mirror.omim.org/entry/603684
• UniProt: http://www.uniprot.org/uniprot/Q9Y5X9.html