Meprin A subunit beta; endopeptidase-2; Meprin B; N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta; PABA peptide hydrolase; PPH beta (MEP1B)

Function

• hydrolysis of proteins, including azocasein, & peptides
• hydrolysis of 5-His-|-Leu-6, 6-Leu-|-Cys-7, 14-Ala-|-Leu-15 & 19-Cys-|-Gly-20 bonds in insulin B chain
• homotetramer consisting of disulfide-linked beta subunits
• heterotetramer of two alpha & two beta subunits formed by non-covalent association of two disulfide-linked heterodimers (putative)
• interacts with MBL2 through its carbohydrate moiety; interaction may inhibit its catalytic activity (putative)

Cofactor:

• binds 1 Zn+2 per subunit (putative)

Structure

• N-glycosylated; contains high mannoase &/or complex biantennary structures (putative)
• belongs to the peptidase M12A family
• contains 1 EGF-like domain
• contains 1 MAM domain
• contains 1 MATH domain

Compartment

• membrane; single-pass type 1 membrane protein

More general terms

• plasma membrane protein
• glycoprotein
• protein subunit

Component of

• meprin (endopeptidase-2)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4225
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4225
• OMIM: https://mirror.omim.org/entry/600389
• UniProt: http://www.uniprot.org/uniprot/Q16820.html