meprin (endopeptidase-2)

Function

• hydrolysis of protein & peptide substrates preferentially on carboxyl side of hydrophobic residues
• hydrolysis of proteins, including azocasein, & peptides
• hydrolysis of 5-His-|-Leu-6, 6-Leu-|-Cys-7, 14-Ala-|-Leu-15 & 19-Cys-|-Gly-20 bonds in insulin B chain
• interacts with MBL2 through its carbohydrate moiety; interaction may inhibit its catalytic activity (putative)

Structure

• heterotetramer of two alpha & two beta subunits formed by non-covalent association of two disulfide-linked heterodimers (putative)

Compartment

• membrane

More general terms

• zinc metalloprotease
• multisubunit protein