tumor necrosis factor ligand superfamily member 9; 4-1BB ligand; 4-1BBL (TNFSF9)

Function

• cytokine that binds to TNFRSF9
• induces proliferation of activated peripheral blood T-cells
• may have a role in activation-induced cell death
• may play a role in cognate interactions between T-cells & B-cells/macrophages

Structure

• homotrimer (putative)
• belongs to the tumor necrosis factor family

Compartment

membrane

Expression

• expressed in brain, placenta, lung, skeletal muscle & kidney

More general terms

• tumor necrosis factor (TNF) family protein

Additional terms

• CD137; tumor necrosis factor receptor superfamily member 9; 4-1BB ligand receptor; T-cell antigen 4-1BB homolog; T-cell antigen ILA; CDw137 (TNFRSF9, CD137, ILA)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8744
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8744
• OMIM: https://mirror.omim.org/entry/606182
• UniProt: http://www.uniprot.org/uniprot/P41273.html