voltage-dependent Ca+2 channel alpha-2/delta-1 (L type, dihydropyridine-sensitive, CACNA2D1, CACNL2A, CCHL2A)
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Function
- alpha-2/delta subunit of voltage-dependent Ca+2 channel
- regulates Ca+2 current density & activation/inactivation kinetics of the Ca+2 channel
- dimer formed of alpha-2-1 & delta-1 chains, disulfide- linked
- voltage-dependent Ca+2 channels are multisubunit complexes, consisting of alpha-1 (CACNA1), alpha-2 (CACNA2D), beta (CACNB) & delta (CACNA2D) subunits in a 1:1:1:1 ratio
- may be proteolytically processed into subunits alpha-2-1 & delta-1 (putative)
- role in excitation-contraction coupling (putative)
- binds gabapentin
Structure
- MIDAS-like motif in the VWFA domain binds divalent metal cations & is required to promote trafficking of alpha-1 (CACNA1) subunit to the plasma membrane by an integrin-like switch (putative)
- belongs to the Ca+2 channel subunit alpha-2/delta family
- contains 1 cache domain
- contains 1 VWFA domain
Compartment
membrane
Expression
- central nervous system, skeletal muscle & aorta tissues
More general terms
Additional terms
Component of
References
- ↑ Williams ME et al Structure and functional expression of an omega-conotoxin- sensitive human N-type calcium channel. Science. 1992 Jul 17;257(5068):389-95. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1321501
- ↑ Witcher DR, De Waard M, Sakamoto J, Franzini-Armstrong C, Pragnell M, Kahl SD, Campbell KP. Subunit identification and reconstitution of the N-type Ca2+ channel complex purified from brain. Science. 1993 Jul 23;261(5120):486-9. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8392754
- ↑ Campbell KP et al The biochemistry and molecular biology of the dihydropyridine-sensitive calcium channel. TINS 11:425 1988 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2469159
- ↑ Monthly Prescribing Reference http://www.PrescribingReference.com