voltage-dependent Ca+2 channel alpha-2/delta

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Introduction

The alpha-2 & delta subunits of the voltage-dependent Ca+2 channel are proteolytically processed from the same precursors (voltage-dependent Ca+2 channel alpha-2/delta); however, it is unclear whether cleavage really takes place in vivo & has a functional role

More general terms

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References

  1. Williams ME et al Structure and functional expression of an omega-conotoxin- sensitive human N-type calcium channel. Science. 1992 Jul 17;257(5068):389-95. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1321501
  2. Witcher DR, De Waard M, Sakamoto J, Franzini-Armstrong C, Pragnell M, Kahl SD, Campbell KP. Subunit identification and reconstitution of the N-type Ca2+ channel complex purified from brain. Science. 1993 Jul 23;261(5120):486-9. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8392754
  3. Campbell KP et al The biochemistry and molecular biology of the dihydropyridine-sensitive calcium channel. TINS 11:425 1988 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2469159