interferon regulatory factor 2-binding protein 1 (IRF-2-binding protein 1, IRF-2BP1, IRF2BP1)

Function

acts as a transcriptional repressor

• acts as a transcriptional corepressor (RF2-dependent)
• repression is not mediated histone deacetylase
• interacts with IRF2
• part of a corepressor complex containing IRF2 & IRF2BP2

Structure

• C-terminal RING-type Zn+2 finger domain is necessary for interaction with BAP1
• belongs to the IRF2BP family
• contains 1 RING-type Zn+2 finger

Compartment

nucleus

More general terms

• transcriptional silencer (transcriptional repressor)
• ring finger protein
• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2614
• UniProt: http://www.uniprot.org/uniprot/Q8IU81.html