Rho GTPase-activating protein 27 (Rho-type GTPase-activating protein 27, CIN85-associated multi-domain-containing Rho GTPase-activating protein 1, ARHGAP27, CAMGAP1, PP905)

Function

• Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis
• GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state
• has activity toward CDC42 & RAC1 (putative)
• interacts with SH3KBP1/CIN85 (putative)

Structure

contains 1 PH domain contains 1 Rho-GAP domain contains 1 SH3 domain contains 3 WW domains

Compartment

• cytoplasm (putative), peripheral membrane (putative)

Alternative splicing

named isoforms=4

Expression

• expressed in germinal center B-cell, spleen

Pathology

• expressed in chronic lymphocytic leukemia, pancreatic cancer & lung cancer

More general terms

• rho GTPase-activating protein (rho-GAP)
• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2011
• UniProt: http://www.uniprot.org/uniprot/Q6ZUM4.html