nuclear protein NP60; nuclear protein of 60 kD; 3-hydroxyisobutyrate dehydrogenase-like protein; cytokine-like nuclear factor N-PAC (NP60, GLYR1, HIBDL)

Function

• regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 & specifically regulating MAPK14 signaling
• indirectly promotes phosphorylation of MAPK14 & activation of ATF2
• phosphorylation of MAPK14 requires upstream activity of MAP2K4 & MAP2K6
• interacts with MAPK14

Structure

• A.T hook DNA-binding domain is required for interaction with MAPK14
• belongs to the 3-hydroxyisobutyrate dehydrogenase family, NP60 subfamily
• contains 1 A.T hook DNA-binding domain
• contains 1 PWWP domain

Compartment

nucleus

Alternative splicing

named isoforms=4

More general terms

• nuclear protein
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q49A26.html