pleckstrin homology domain-containing family M member 1 (162 kD adapter protein, AP162, PLEKHM1, KIAA0356)
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Function
- appears to be implicated in the development of osteopetrosis (diminished bone resorption) with a function in vesicular transport in the osteoclast
- may have a role in sialyl-lex-mediated transduction of apoptotic signals
- in colon carcinoma & breast carcinoma cells, it interacts with sialyl-lex-positive protein
Structure
- contains 2 PH domains
- contains 1 phorbol-ester/DAG-type zinc finger
- contains 1 RUN domain
Compartment
Expression
- expressed in placenta, liver, prostate, thymus, spleen, ovary, colon, colon carcinoma & peripheral blood lymphocytes
- weakly expressed in brain, lung, kidney, & testis
- no expression in heart, skeletal muscle, pancreas & small intestine
Pathology
- expressed in the breast carcinoma cell line MCF-7
Notes
sialyl-lex is a carcinoma associated antigen