molecular features of molecular adenocarcinoma
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Genetics
- familial adenomatous polyposis coli (APC-gene)
- mutation in k-ras proto-oncogene
- deleted in colon carcinoma (DCC) gene
- mutated in colon carcinoma (MCC) gene
- defects in p53
serum carcinoembryonic antigen elevated, marker of recurrence CEACAM7 strongly down-regulated in colonic adenocarcinomas