tRNA-specific adenosine deaminase 3 (tRNA-specific adenosine-34 deaminase subunit ADAT3, ADAT3)

Function

• role in deamination of adenosine-34 to inosine in many tRNAs
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• belongs to the cytidine & deoxycytidylate deaminase family, ADAT2 subfamily
• in contrast to other cytidine & deoxycytidylate deaminase family members, lacks conserved Glu-255 active site, replaced by a Val-225, thus may function as enzyme regulatory subunit

Cofactor: Zn+2

More general terms

• tRNA-specific adenosine deaminase
• phosphoprotein

Additional terms

• adenosine deaminase (adenosine aminohydrolase, ADA)

Database

• UniProt: http://www.uniprot.org/uniprot/Q96EY9.html