JmjC domain-containing histone demethylation protein 1B; [histone-H3]-lysine-36 demethylase 1B; F-box/LRR-repeat protein 10; F-box & leucine-rich repeat protein 10; F-box protein FBL10; protein JEMMA; Jumonji domain-containing EMSY-interactor methyltransferase motif protein; CXXC-type zinc finger protein 2; protein-containing CXXC domain 2 (FBXL10, KDM2B, CXXC2, FBL10, JHDM1B, PCCX2)
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Function
- histone demethylase
- specifically demethylates Lys-36 of histone H3, thus role in histone code
- weak or no activity for mono- & tri-methylated H3 Lys-36
- substrate-recognition component of the SCF-type* E3 ubiquitin ligase complex
- interacts with SKP1A & CUL1
- JmjC domain mediates the demethylation activity
* SCF: SKP1-CUL1-F-box protein
protein 6-N,6-N-dimethyl-L-lysine + 2-oxoglutarate + O2
<-->
protein 6-N-methyl-L-lysine + succinate + formaldehyde + CO2
Cofactor: binds 1 Fe+2 ion per subunit
Structure
- belongs to the JHDM1 histone demethylase family
- contains 1 CXXC-type zinc finger
- contains 1 F-box domain
- contains 1 JmjC domain
- contains 4 LRR repeats (leucine-rich repeats)
- contains 1 PHD-type zinc finger
Compartment
Alternative splicing
named isoforms=3
More general terms
- JmjC domain-containing protein (JMJD)
- dioxygenase
- histone demethylase
- phosphoprotein
- zinc finger protein