Myc target protein 1 (Myc target in myeloid cells protein 1, MYCT1, MTLC, MTMC1)

Function

• may regulate certain MYC target genes, MYC seems to be a direct upstream transcriptional activator
• does not seem to significantly affect cell growth
• overexpression seems to mediate many of the known phenotypic features associated with MYC, including promotion of apoptosis, alteration of morphology, enhancement of anchorage-independent growth, tumorigenic conversion, promotion of genomic instability, & inhibition of hematopoietic differentiation (putative)

Structure

belongs to the MYCT1 family

Compartment

• nucleus
• expressed in nuclei ofhepatocellular carcinoma cell line Bel7402 cells

Pathology

• down-regulated in gastric cancer tissues

Notes

uncertain whether Met-1 or Met-49 is the initiator

More general terms

• nuclear protein
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q8N699.html