presenilin-1 (PS-1) knockout mouse
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Introduction
Phenotype includes:
- markedly abnormal somatogenesis & axial skeletal development
- shortened body length
- cerebral hemorrhages
- death just before or at birth
- abnormal embryonic neurodevelopment of forebrain
- premature loss of neuronal precursors
Biochemical features:
- normal levels of amyloid precursor protein (APP)
- accumulation of APP-gamma secretase substrates, APP C83 & C99 fragments
More general terms
Additional terms
References
- ↑ Selkoe DJ. Alzheimer's disease: genes, proteins, and therapy. Physiol Rev. 2001 Apr;81(2):741-66. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11274343