cisplatin resistance-associated overexpressed protein; cAMP regulatory element-associated protein 1; CRE-associated protein 1; CREAP-1; Luc7A; okadaic acid-inducible phosphoprotein OA48-18 (CROP, CREAP1, LUC7L3, O48)

Function

• binds cAMP regulatory element DNA sequence
• role in RNA splicing (putative)
• may interact with SFRS1 & form homodimers
• phosphorylated in vitro by SRPK1, SRPK2 & CLK1
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

belongs to the Luc7 family

Compartment

• nucleus speckle
• subnuclear localization is affected by cisplatin

Alternative splicing

named isoforms=2

Expression

• widely expressed
• highest levels in heart, brain, pancreas, thymus, ovary, small intestine, peripheral blood leukocytes, cerebellum, putamen, pituitary
• lowest levels in lung, liver and kidney
• also expressed in fetal tissues, including brain, heart, kidney, thymus, lung

More general terms

• DNA-binding protein
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/O95232.html