Bcl10-interacting CARD protein (BinCARD, C9orf89)

Function

• role in inhibiting the effects of BCL10-induced activation of NF-kappa-B
• may inhibit phosphorylation of BCL10 (CARD-dependent)
• associates with BCL10 by CARD-CARD interaction
• phosphorylated on Ser-113 upon DNA damage, probably by ATM or ATR (isoform 2)

Structure

contains 1 CARD domain

Compartment

• nucleus
• co-expression with BCL10 induces translocation from nucleus to cytosol

Alternative splicing

named isoforms=2

Expression

• expressed in ovary, testis, placenta, skeletal muscle, kidney, lung, heart, liver
• expressed in thymus, brain

More general terms

• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q96LW7.html