pyrin domain-containing protein 1; pyrin-only protein 1; PAAD-only protein (PYDC1, ASC2, ASCI, POP1, PYC1)
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Function
- associates with apoptosis-associated specklike protein containing a CARD domain (PYCARD) & modulates its ability to collaborate with pyrin & cryopyrin in NF-kappa-B & pro- caspase-1 activation
- suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes & inhibits NF-kappa-B activation by cytokines & LPS
- interacts with PYCARD/ASC
- phosphorylated
Structure
contains 1 DAPIN domain
Compartment
Alternative splicing
named isoforms=1
Expression
- predominantly expressed in monocytes, macrophages & granulocytes