Pre-mRNA-splicing factor SLU7 (hSlu7, SLU7)

Function

• role in catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon 1 attacks the 3'-plice site to generate spliced mRNA & the excised lariat intron
• required for holding exon 1 properly in the spliceosome & for correct AG identification when more than one possible AG exists in 3'-splicing site region
• may be involved in activation of proximal AG
• role in alternative splicing regulation (probable)
• component of late spliceosomal complexes
• associates with spliceosome prior to recognition of 3'-splice site

Structure

• belongs to the SLU7 family
• contains 1 CCHC-type zinc finger required to retain protein within the nucleus & prevent its shuttle back to cytoplasm via the CRM1 pathway

Compartment

• nucleus, cytoplasm, predominantly nuclear
• shuttling between nucleus & cytoplasm is regulated by the CCHC-type zinc finger
• upon UV-C stress stimulus, nuclear concentration decreases, affecting alternative splicing

More general terms

• splicing factor; snRNP-associated protein
• zinc finger protein
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/605974
• UniProt: http://www.uniprot.org/uniprot/O95391.html