myopalladin (145 kD sarcomeric protein, MYPN. MYOP)

Function

• component of the sarcomere
• tethers together nebulin (skeletal muscle) & nebulette (cardiac muscle) to alpha-actinin, at the Z lines
• interacts with titin, NEB, NEBL, ACTN2 & CARP

Structure

• contains 5 Ig-like domains (immunoglobulin-like)

Compartment

• cytoplasm, nucleus
• bound to sarcomere both at the Z-line periphery & in the central I-band region

Alternative splicing

named isoforms=3

Expression

• expressed in adult skeletal muscle & fetal heart

More general terms

• phosphoprotein

Component of

• sarcomere

Database

• OMIM: https://mirror.omim.org/entry/608517
• UniProt: http://www.uniprot.org/uniprot/Q86TC9.html