Nebulette; actin-binding Z-disk protein (NEBL)

Function

• binds to actin & plays an important role in assembly of the Z-disk

Structure

• contains 23 nebulin repeats
• contains 1 SH3 domain

Expression

• abundantly expressed in cardiac muscle
• not expressed in skeletal or smooth muscle
• localized to Z-lines in cardiac cells & to dense bodies in nonmuscle cells

More general terms

• cytoskeletal protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10529
• OMIM: https://mirror.omim.org/entry/605491
• UniProt: http://www.uniprot.org/uniprot/O76041.html