alpha-internexin (alpha-Inx, 66 kD neurofilament protein, neurofilament-66, NF-66, INA)

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Function

Structure

Expression

  • expressed predominantly in adult CNS
  • expressed in brain as early as 16th week of gestation
  • reaches steady state level by the 18th week of gestation
  • rat brain alpha-internexin mRNA levels are maximal prior to birth & decline into adulthood, while the converse is seen for NF-L.[1]
  • expressed by most if not all developing neurons.[2]

More general terms

References

  1. 1.0 1.1 Fleigner et al EMBO J 1990 Mar;9(3):749-55
  2. 2.0 2.1 Cairns NJ, Lee VM, Trojanowski JQ. The cytoskeleton in neurodegenerative diseases. J Pathol. 2004 Nov;204(4):438-49. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15495240
  3. UniProt http://www.uniprot.org/uniprot/Q16352.html

Database