alpha-internexin (alpha-Inx, 66 kD neurofilament protein, neurofilament-66, NF-66, INA)
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Function
- class-4 neuronal intermediate filament
- able to self-assemble or co-assemble with neurofilament proteins to form intermediate filaments
- role in morphogenesis of neurons
- may form independent structural network without involvement of other neurofilaments
- may cooperate with NF-L to form filamentous backbone to which NF-M & NF-H attach to form cross-bridges
Structure
- O-glycosylated
- belongs to the intermediate filament family
Expression
- expressed predominantly in adult CNS
- expressed in brain as early as 16th week of gestation
- reaches steady state level by the 18th week of gestation
- rat brain alpha-internexin mRNA levels are maximal prior to birth & decline into adulthood, while the converse is seen for NF-L.[1]
- expressed by most if not all developing neurons.[2]
More general terms
References
- ↑ 1.0 1.1 Fleigner et al EMBO J 1990 Mar;9(3):749-55
- ↑ 2.0 2.1 Cairns NJ, Lee VM, Trojanowski JQ. The cytoskeleton in neurodegenerative diseases. J Pathol. 2004 Nov;204(4):438-49. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15495240
- ↑ UniProt http://www.uniprot.org/uniprot/Q16352.html