kinesin-associated protein 3 (Smg GDS-associated protein, KIFAP3, SMAP)

Function

• tethering the chromosomes to the spindle pole
• chromosome movement
• binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex
• regulates membrane binding of heterotrimeric KIF3 complex
• interacts with RAP1GDS1/SMG GDS.
• interacts with SMC3 subunit of the cohesin complex
• phosphorylated on Tyr by SRC in vitro
  • diminishes binding affinity for RAP1GDS1

More general terms

• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/601836
• UniProt: http://www.uniprot.org/uniprot/Q92845.html