SH2B adapter protein 3 (lymphocyte-specific adapter protein Lnk,signal transduction protein Lnk, lymphocyte adapter protein, SH2B3, LNK)

Function

• links T-cell receptor activation signal to PLC-gamma-1, GRB2 & PI3-kinase
• binds to the tyrosine-phosphorylated TCR zeta chain via its SH2 domain
• Tyr phosphorylated by LCK Preferentially expressed by lymphoid cell lines

More general terms

• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/605093
• UniProt: http://www.uniprot.org/uniprot/Q9UQQ2.html