T cell receptor zeta

Function

• the T-cell receptor forms non covalent interactions with a series of transmembrane signalling subunits, delta, gamma, epsilon & zeta each of which contains 1-3 copies of the motif YXX[LI]X(6-8)YXX[LI]
• phosphorylation of these Tyr-containing sites in antigen- stimulated T-cells (presumably by lck) creates a binding site(s) for the SH2-domains of Zap-70.
• Zap-70, in turn stimulates PLC-gamma1, leading to the rise in intracellular Ca+2

More general terms

• T cell receptor signalling subunit

Additional terms

• lck proto-oncogene protein
• phospholipase C-gamma 1 (PLCG1, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1, PLC-2)
• Zap-70 tyrosine kinase; zeta-associated protein 70 kD; Syk-related tyrosine kinase (ZAP70, SRK)

Component of

• T cell receptor