synaptic vesicle glycoprotein 2A (SV2A, KIAA0736, PSEC0174)
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Function
- control of regulated secretion in neural & endocrine cell
- selectively enhances low-frequency neurotransmission
- positively regulates vesicle fusion
- maintains readily releasable pool of secretory vesicles
- interacts with SYT1/synaptotagmin-1 (Ca+2-dependent)
- binds adapter protein complex AP-2
- phosphorylation by CK1 of the N-terminal cytoplasmic domain regulates interaction with SYT1
- N-glycosylated
- brain binding-site for the antiepileptic drug levetiracetam
Compartment
- cytoplasmic vesicle, secretory vesicle, synaptic vesicle, synaptic vesicle membrane
- enriched in chromaffin granules
- not present in adrenal microsomes
- associated with both insulin granules & synaptic-like microvesicles in insulin-secreting cells of the pancreas
Alternative splicing
named isoforms=2
Expression
Radiology
* 11C-UCB-J-PET apparently an SV2A analog[2]
More general terms
Additional terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q7L0J3.html
- ↑ 2.0 2.1 2.2 2.3 Chen MK, Mecca AP, Naganawa M et al Assessing Synaptic Density in Alzheimer Disease With Synaptic Vesicle Glycoprotein 2A Positron Emission Tomographic Imaging. JAMA Neurol. Published online July 16, 2018. PMID: https://www.ncbi.nlm.nih.gov/pubmed/30014145 https://jamanetwork.com/journals/jamaneurology/fullarticle/2687472
Mormino EC, Jagust WJ. A New Tool for Clinical Neuroscience - Synaptic Imaging. JAMA Neurol. Published online July 16, 2018 PMID: https://www.ncbi.nlm.nih.gov/pubmed/30014142 https://jamanetwork.com/journals/jamaneurology/fullarticle/2687466