TBC1 domain family member 2A; armus; prostate antigen recognized & identified by SEREX 1; PARIS-1 (TBC1D2, PARIS1, PP8997, TBC1D2A)

Function

• GTPase-activating protein for RAB7A
• signal effector acting as a linker between RAC1 & RAB7A, leading to RAB7A inactivation & subsequent inhibition of cadherin degradation & reduced cell-cell adhesion
• interacts with activated RAC1 & CDH1

Structure

• contains 1 PH domain
• contains 1 Rab-GAP TBC domain

Compartment

• cytoplasm, cytoplasmic vesicle
• cell junction

Alternative splicing

named isoforms=6

Expression

• expressed in a broad range of tissues, including kidney, liver, lung, placenta, keratinocytes & epithelium-containing organs

Pathology

• isoform 2 is differentially expressed in prostate normal vs malignant cells

More general terms

• TBC1 domain family member
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55357
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:55357
• OMIM: https://mirror.omim.org/entry/609871
• UniProt: http://www.uniprot.org/uniprot/Q9BYX2.html