TBC1 domain family member 1 (TBC1D1, KIAA1108)

Function

• GTPase activating protein for Rab family protein (putative)
• role in the cell cycle & differentiation of various tissues (putative)
• role in trafficking & translocation of GLUT4-containing vesicles & insulin-stimulated glucose uptake into cells
• insulin-stimulated phosphorylation of TBC1D1 by AKT kinases stimulates SLC2A4/GLUT4 translocation

Structure

• contains 1 PID domain
• contains 1 Rab-GAP TBC domain

Compartment

nucleus

Alternative splicing

named isoforms=2

More general terms

• TBC1 domain family member
• nuclear protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23216
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23216
• OMIM: https://mirror.omim.org/entry/609850
• UniProt: http://www.uniprot.org/uniprot/Q86TI0.html