fibroblast growth factor receptor substrate 3; FGFR substrate 3; Suc1-associated neurotrophic factor target 2; SNT-2; FGFR signalling adaptor SNT2 (FRS3)

Function

• adapter protein that links FGR & NGF receptors to downstream signaling pathways
• activation of MAP kinases
• down-regulates ERK2 signaling by interfering with phosphorylation & nuclear translocation of ERK2
• phosphorylated on Tyr upon stimulation by BFGF or NGFB
• phosphorylated by ULK2 in vitro
• binds NTRK1, FGFR1, NGFR, GRB2, PTPN11, ERK2

Structure

contains 1 IRS-type PTB domain

Compartment

membrane, lipid-anchor

More general terms

• receptor
• myristoylated protein

Additional terms

• fibroblast growth factor
• fibroblast growth factor receptor substrate
• fibroblast growth factor [FGF] receptor

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10817
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10817
• OMIM: https://mirror.omim.org/entry/607744
• UniProt: http://www.uniprot.org/uniprot/O43559.html