Abl interactor 2; Abelson interactor 2; Abi-2; Abl-binding protein 3; AblBP3; Arg-binding protein 1; ArgBP1 (ABI2, ARGBPIA)

Function

• regulation of cell growth & transformation
• interacts with nonreceptor tyrosine kinases ABL1 &/or ABL2
• cytoskeletal reorganization
• regulates ABL1-mediated phosphorylation of MENA
• interacts with ABL1 & ABL2
• substrate for ABL1
• component of the WAVE complex
• interacts with the Arp2/3 complex

Structure

• belongs to the ABI family
• contains 1 SH3 domain
• contains 1 t-SNARE coiled-coil homology domain

Compartment

• cytoplasm
• isoform 1 localized to protruding lamellipodia & filopodia tips

Alternative splicing

named isoforms=4

More general terms

• phosphoprotein

Component of

• WAVE1 complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10152
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10152
• OMIM: https://mirror.omim.org/entry/606442
• UniProt: http://www.uniprot.org/uniprot/Q9NYB9.html