docking protein 6; downstream of tyrosine kinase 6 (DOK6, DOK5L)

Introduction

Docking proteins interact with receptor tyrosine kinases & mediate particular biological responses.

Function

• DOK6 promotes RET-mediated neurite growth
• may have a role in brain development &/or maintenance
• on Ret activation, phosphorylated on one or more C-terminal Tyr by an Src family kinase
• interacts via its PTB domain with phosphorylated RET

Structure

• PTB domain mediates receptor interaction (putative)
• belongs to the DOK family, type B subfamily
• contains 1 IRS-type PTB domain
• contains 1 PH domain

Expression

• highly expressed in fetal & adult brain
• highly expressed in the cerebellum
• weak expression in kidney, spinal cord & testis.

More general terms

• phosphoprotein
• nuclear protein
• docking protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=220164
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:220164
• OMIM: https://mirror.omim.org/entry/611402
• UniProt: http://www.uniprot.org/uniprot/Q6PKX4.html